|Category:||College of Engineering - BNG|
|Date & Time:||
Thursday , 10/11/2012
from 12:30 PM to 01:45 PM
Topic: Understanding dynamic markers of physiological disorders using engineering
Speaker: Dr. Premananda Indic, Research faculty, Department of Neurology, University of Massachusetts Medical School
Abstract: In this talk, I will discuss how engineering principles from nonlinear dynamics can be applied to understand the abnormal behavior of physiological rhythms during certain pathological conditions, as well as new methods that can be developed for quantifying and restoring rhythmicity. I will demonstrate that physiological signals contain dynamic markers of vulnerability. By employing nonlinear signal processing tools, we are able to extract this hidden information. In addition I will show that biological tissues composed of a population of coupled cellular oscillators that are responsible for generating these physiological rhythms, exhibit a variety of complex behaviors. Based on the theory of coupled oscillators, we derive conditions for different states of a network and apply this theoretical formulation to understand the dynamics of cellular oscillators. Our analysis reveals several salient features of physiological disorders such as suicidal thinking in major depression, apnea in preterm infants and seizures in epileptic patients. I will also discuss our effort in building a therapeutic intervention device for the reduction of apnea episodes in preterm infants admitted to neonatal intensive care units.
|Additional Info:||Dr. Indic's Profile|