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Bioengineering Presentation by Dr. Kidong Park |
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| Category: | College Of Engineering | |
| Date & Time: |
Tuesday , 10/09/2012 from 12:30 PM to 01:30 PM |
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| Location: | Txt - 102 | |
| Admission: | Free! | |
| Sponsored by: | BNG Faculty Search Committee | |
| Contact: |
Dr. Yong Kim ykim@umassd.edu 508-999-8452 |
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| Description: | TOPIC: MEMS technologies for mechanical characterization on a single cell level ABSTRACT:MEMS (micro electromechanical system) are highly miniaturized electromechanical devices with a typical dimension between a few to a few hundred µm. Due to its small size and high precision, MEMS technologies are actively studied as break-through technologies to directly characterize various cellular properties, opening up a new possibility to expand our understanding in various aspects of cellular metabolism and physiology. Recent studies in the field of mechano-biology revealed that the mechanical properties of cell can be used as effective parameters to represent cell status and complex cellular process. For instance, the mass or the growth rate of a cell is directly related to the synthesis and accumulation rate of proteins, DNA, and other large molecules inside the cell during cell growth and division. Therefore, detailed characterization of mass and growth rate on a single cell level can lead to deeper understanding in the intrinsic mechanism of coordination between cell cycle and cell growth. Also, the stiffness of a cell is reported to be a very important parameter affecting cellular differentiation, cancer metastasis and cell spreading. This talk will focus on the principle of resonant MEMS mass sensors and their applications in the characterization of mass, growth rate and mechanical stiffness of adherent human colorectal carcinoma cells (HT29) on a single cell level. Single HT29 cells are cultured on the sensor surface and the mass of the target cell was repeatedly measured in a least invasive manner, while the cells are growing on the sensor. The detailed characterization of the growth rate confirmed the exponential growth model instead of the linear growth model, which has been of great interest for over 50 years. Also, the stiffness of the cell was extracted by comparing the measured mas of live cells to that of fixed cells. Besides, interesting applications of the developed sensors in physical characterization of micro-scaled objects will be presented. Biography: Kidong Park received the B.S. degree in electrical engineering from Seoul National University, Seoul, Korea, in 1999, and the Ph.D. degree in electrical and computer engineering from Purdue University, West Lafayette, IN, in 2009. From 2009 to 2010, he was a Postdoctoral Research Associate with the Micro and Nanotechnology Laboratory, University of Illinois at Urbana–Champaign (UIUC), Urbana. From January 2011 to October 2011, he was a Senior Engineer with Samsung Electronics. He is currently a Postdoctoral Research Associate with the Micro and Nanotechnology Laboratory, UIUC, where he is also with the Department of Electrical and Computer Engineering. His current research interests include modeling, design, fabrication, and characterization of miomicroelectromechanical systems sensors and microfluidic devices for medical diagnostic and cellular studies. | |
