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Chemistry and Biochemstry Department Seminar
|Category:||College Of Arts And Sciences|
|Date & Time:||
from 04:00 PM to 05:30 PM
|Sponsored by:||Chemistry & Biochemistry Deptartment|
Dr. Sivappa Rasapalli
TITLE: "Combining Organic Synthesis and Directed Evolution to Design HIV Vaccines"
We will describe an approach to designing and synthesizing carbohydrate structures which can be tested as HIV vaccine candidates. Some HIV positive individuals mount a protective antibody response against the disease and remain healthy, and their antibodies are a source of clues as to how the virus might be defeated. 2G12 is one such antibody, which neutralizes a broad range of HIV strains and protects against infection. To stimulate production of 2G12-like antibodies in a typical individual, it will be necessary to design and synthesize a molecule which mimics the viral cluster of carbohydrates which is recognized by 2G12. We have developed a strategy for addressing this problem with a combination of carbohydrate synthesis, click chemistry and directed evolution.