Bioengineering SeminarDate(s): 4/30/2013 5:00 PM - 4/30/20136:00 PM
Location: Tex 102
Contact: Qinguo Fan email@example.com 508-999-9147
Dr. Pryune's website
From yeast to muscles - Using model systems to understand how cells build their cytoskeleton
A cytoskeleton of actin filaments provides an organizing framework within the cells of our body, with the contractile elements of muscle cells representing the most elaborate of actin structures. Precisely how various actin-containing structures are assembled is an area of great research interest. Using successively more complicated systems, from biochemical assays through the single-celled budding yeast, and finally the simple model worm Caenorhabditis elegans, we have developed a model for how actin filament-organizing proteins called Formins help assemble actin-based structures, including the complex contractile apparatus of striated muscles.